Redox Regulation of Autophagy in Dilated and Hypertrophic Cardiomyopathy

Authors

  • Mingjie Yang Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 210032, China
  • Yingmei Zhang Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 210032, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
  • Jun Ren Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 210032, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA

Keywords:

Autophagy; Dilated cardiomyopathy; Hypertrophic cardiomyopathy; Oxidative stress

Abstract

Autophagy is an essential intercellular degrading system for protein aggregates and organelle turnover. Disruption of autophagic flux will disturb cellular homeostasis and influence different cardiovascular diseases including cardiomyopathy. However, no agreement has been reached about whether autophagy ameliorates or exacerbates the pathological development of cardiomyopathy. This review will try to compare the different roles of autophagy in dilated and hypertrophic cardiomyopathies. In addition, oxidative stress is interconnected with autophagy in various aspects, and as such, we will also offer some details of this interplay in cardiomyopathy.

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Published

2018-05-01

How to Cite

Yang, M., Zhang, Y., & Ren, J. (2018). Redox Regulation of Autophagy in Dilated and Hypertrophic Cardiomyopathy. Reactive Oxygen Species, 5(15), 159–166. Retrieved from https://rosj.org/index.php/ros/article/view/135

Issue

Vol. 5 No. 15 (2018)

Section

REVIEW ARTICLES

License

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