Toxicity of Titanium Dioxide Nanoparticles Induced by Reactive Oxygen Species

Authors

  • Di Zhou Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Shuo Han Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Tenglong Yan Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Changmao Long Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Jiayu Xu Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Pai Zheng Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Zhangjian Chen Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China
  • Guang Jia Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China

Keywords:

Nanomaterial; Oxidative stress; Reactive oxide species; Titanium dioxide nanoparticle; Toxicity

Abstract

Titanium dioxide nanoparticles (TiO2 NPs) are one of the most widely used types of nanoparticles which can be used in food additives and drugs. However, the safety of TiO2 NPs is still controversial and the biological mechanism of TiO2 NPs-induced toxicity is not clear yet. We reviewed the research about toxicity of TiO2 NPs induced by reactive oxygen species (ROS) in vitro or in vivo. TiO2 NPs could induce significant increase of ROS and excessive free radicals, destroying redox balance. ROS-mediated oxidative stress leads to the occurrence of lipid and protein peroxidation, which in turn would induce autophagy, apoptosis, and necrosis of cells. Increased ROS production induced by TiO2 NPs was generally associated with inflammatory response, mitochondrial dysfunction, and genetic damage in vitro and in vivo. Although ROS may play an important role in TiO2 NPs-induced biological effects, the specific way it produces and its complex relationship with subsequent biological effects need to be further clarified.

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Published

2019-09-01

How to Cite

Zhou, D., Han, S., Yan, T., Long, C., Xu, J., Zheng, P., Chen, Z., & Jia, G. (2019). Toxicity of Titanium Dioxide Nanoparticles Induced by Reactive Oxygen Species. Reactive Oxygen Species, 8(23), 267–275. Retrieved from https://rosj.org/index.php/ros/article/view/243

Issue

Vol. 8 No. 23 (2019)

Section

REVIEW ARTICLES

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