The US FDA-Approved Drug Dimethyl Fumarate, an Nrf2 Activator, for Treating Multiple Sclerosis: The Mechanisms of Action Revisited
Keywords:Dimethyl fumarate; Epigenetics; Immunity; Monocytes; Multiple sclerosis; Nrf2; Reactive oxygen species
Dimethyl fumarate, a potent Nrf2 activator and antioxidant-inducing compound, has been approved by the US Food and Drug Administration (FDA) as a first-line drug for treating relapsing forms of multiple sclerosis (MS). Two latest studies published in Nat Commun demonstrated that the efficacy of the drug in treating MS may be associated with increased reactive oxygen species production instead.
(First online: Feb 23, 2021)
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