Hemoglobin Is Not a Biological Fenton Reagent

Authors

  • Philip G. Penketh Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA

DOI:

https://doi.org/10.20455/ros.2022.c.801

Keywords:

Fe(IV); Ferryl iron; Hemoglobin; Hydrogen peroxide; Hydroxyl radical; Thiourea; Urate

Abstract

Hemoglobin has been reported to be a biological Fenton reagent, as a consequence of oxidations believed to be produced by hydroxyl radicals. These hydroxyl radicals were thought to be generated from the reaction of hemoglobin with hydrogen peroxide. However, the oxidations that were observed were in fact due to the generation of a strongly oxidizing iron (IV) ferryl species, and not due to hydroxyl radicals.

(First online: March 1, 2022)

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Published

2022-03-01

How to Cite

Penketh, P. G. (2022). Hemoglobin Is Not a Biological Fenton Reagent. Reactive Oxygen Species, 12, c1–c5. https://doi.org/10.20455/ros.2022.c.801

Issue

Section

OPINION & COMMENTARY