Do SNPs in Glutathione S-Transferase-Omega Allow Predictions of the Susceptibility of Vertebrates to SARS-CoV-2?
DOI:
https://doi.org/10.20455/ros.2022.c805Keywords:
ACE2; COVID-19; GST; Polymorphisms; SARS-CoV-2; SNPsAbstract
Infection with the SARS-Cov-2 virus causes COVID-19 in humans and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs, cats, and mustelids. Mink, and very recently hamsters and deer, have been shown to be able to contract the virus and pass it back to humans. However, which animals are susceptible to the virus has been very hard to predict. Many groups have looked at the sequence homology of the angiotensin converting enzyme 2 (ACE2), a receptor for the SARS-Cov-2 virus, across species, but this has had limited success. Similar work on other proteins such as transmembrane serine protease 2 (TMPRSS2), neuropilin-1, and furin have also been unfruitful. Recently, it has been suggested that single nucleotide polymorphisms (SNPs) in the glutathione S-transferase-omega (GSTO) genes of humans could alter viral susceptibility. Therefore, here, the presence of related sequences in vertebrates has been investigated. The SNPs in the GST-omega-1 (GSTO1) gene reported to increase COVID-19 in humans do not appear in the vertebrate species. However, the GST-omega-2 (GSTO2) SNP is represented in several vertebrate species known to have contracted the SAR-CoV-2 virus. Of course, animals may contain unknown SNPs at disruptive points in these genes too. In summary, GSTO1 genes are unlikely, at least at the moment, to be of value in predicting the susceptibility of an animal to the SARS-CoV-2 virus or disease progression, but a further study of the GST-omega-2 genes would be worthwhile. Therefore, more work on SARS-CoV-2 infections on vertebrates is recommended.
(First Online: June 8, 2022)

Downloads
Published
How to Cite
Issue
Section
License
Submission of an original manuscript to the Journal will be taken to mean that it represents original work not previously published; that it is not being considered elsewhere for publication; that the author(s) agrees to assign copyright to the Journal upon acceptance for publication in the Journal, and if accepted for publication, it will be published in the digital format (PDF) and/or in print and it will not be published elsewhere in the same form, for commercial purposes, in any language, without the consent of the Publisher.