Redox Signaling in Doxorubicin-Induced Ferroptosis


  • Editorial Office ROS



Alas1; Cardiomyopathy; Doxorubicin; Ferroptosis; GPx4; HO-1; Nrf2


Doxorubicin is among the most widely used anticancer drugs; however, its clinical use is associated with cardiomyopathy and heart failure. Studies show ferroptosis as a pivotal form of cell death underlying doxorubicin cardiomyopathy. Recently, multiple redox signaling pathways have been discovered to underlie doxorubicin-induced ferroptosis. This Cutting-Edge Research Highlights discusses these latest advances, focusing on pathways involving Nrf2/HO-1, GPx4, and Alas1/heme synthesis.

(First online: February 19, 2023)


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How to Cite

ROS, E. O. (2023). Redox Signaling in Doxorubicin-Induced Ferroptosis. Reactive Oxygen Species, 13, n4–n6.