Redox Signaling in Doxorubicin-Induced Ferroptosis

Authors

  • Editorial Office ROS

DOI:

https://doi.org/10.20455/ros.2023.n803

Keywords:

Alas1; Cardiomyopathy; Doxorubicin; Ferroptosis; GPx4; HO-1; Nrf2

Abstract

Doxorubicin is among the most widely used anticancer drugs; however, its clinical use is associated with cardiomyopathy and heart failure. Studies show ferroptosis as a pivotal form of cell death underlying doxorubicin cardiomyopathy. Recently, multiple redox signaling pathways have been discovered to underlie doxorubicin-induced ferroptosis. This Cutting-Edge Research Highlights discusses these latest advances, focusing on pathways involving Nrf2/HO-1, GPx4, and Alas1/heme synthesis.

(First online: February 19, 2023)

REFERENCES

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Published

2023-02-19

How to Cite

ROS, E. O. (2023). Redox Signaling in Doxorubicin-Induced Ferroptosis. Reactive Oxygen Species, 13, n4–n6. https://doi.org/10.20455/ros.2023.n803

Issue

Section

CUTTING-EDGE RESEARCH HIGHLIGHTS