Copper Redox Biology: Latest Cutting-Edge Discoveries


  • Editorial Office ROS



Copper; Cuprotosis; Inflammation; Mitochondria; Mucin; Redox


Copper is an essential, yet toxic, trace element whose redox biology has received renewed attention in recent years. Highlighted here are some latest cutting-edge discoveries related to copper redox biology reported in three influential journals—Science, Cell, and Nature, over the past two years.

(First online: Jume 4, 2023)


  1. Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. Cell Res 2019; 29(5):347–64. doi:
  2. Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 2022; 185(14):2401–21. doi:
  3. Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 2022; 375(6586):1254–61. doi:
  4. Reznik N, Gallo AD, Rush KW, Javitt G, Fridmann-Sirkis Y, Ilani T, et al. Intestinal mucin is a chaperone of multivalent copper. Cell 2022; 185(22):4206–15 e11. doi:
  5. Johansson ME, Hansson GC. Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol 2016; 16(10):639–49. doi:
  6. Hansson GC. Mucins and the microbiome. Annu Rev Biochem 2020; 89:769–93. doi:
  7. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med 2019; 25(12):1822–32. doi:
  8. Solier S, Muller S, Caneque T, Versini A, Mansart A, Sindikubwabo F, et al. A druggable copper-signalling pathway that drives inflammation. Nature 2023; 617(7960):386–94. doi:




How to Cite

ROS, E. O. (2023). Copper Redox Biology: Latest Cutting-Edge Discoveries. Reactive Oxygen Species, 13, n13–n15.