Curcumin as an ROS Scavenger in Amyotrophic Lateral Sclerosis

Authors

  • Lucia Chico Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Via Savi 10, 56126 Pisa, Italy
  • Elena Caldarazzo Ienco Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Via Savi 10, 56126 Pisa, Italy
  • Costanza Bisordi Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Via Savi 10, 56126 Pisa, Italy
  • Annalisa Lo Gerfo Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Via Savi 10, 56126 Pisa, Italy
  • Erika Schirinzi Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Via Savi 10, 56126 Pisa, Italy
  • Gabriele Siciliano Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Via Savi 10, 56126 Pisa, Italy

Keywords:

Amyotrophic lateral sclerosis, Oxidative stress, Antioxidants, Autophagy, Curcumin

Abstract

Oxidative stress, a deleterious process resulting from an imbalance between pro-oxidants and anti-oxidative defenses, plays a key role in several neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). Curcumin has been studied for its anti-inflammatory, anti-cancer, and antioxidant effects. Curcuminoids exhibit a protective effect by accelerating antioxidant defense mechanisms and attenuating mitochondrial dysfunction. As a result of epidemiological, clinical, and animal studies, several molecular mechanisms, such as the activation of Nrf2 pathway and the decrease of aberrant proteins aggregation, are emerging to account for the multiple biological effects of curcumin and provide a basis for its potential use in the treatment of ALS. This review focuses on oxidative damage, with particular reference to ALS pathogenesis, and antioxidant defense mechanisms to limit such damage, and summarizes the most interesting in vitro and in vivo studies on the effects of curcumin as an antioxidant and its implications in ALS.

Downloads

Published

2016-09-01

How to Cite

Chico, L., Ienco, E. C., Bisordi, C., Gerfo, A. L., Schirinzi, E., & Siciliano, G. (2016). Curcumin as an ROS Scavenger in Amyotrophic Lateral Sclerosis. Reactive Oxygen Species, 2(5), 339–354. Retrieved from https://rosj.org/index.php/ros/article/view/56

Issue

Vol. 2 No. 5 (2016)

Section

REVIEW ARTICLES

License

Submission of an original manuscript to the Journal will be taken to mean that it represents original work not previously published; that it is not being considered elsewhere for publication; that the author(s) agrees to assign copyright to the Journal upon acceptance for publication in the Journal, and if accepted for publication, it will be published in the digital format (PDF) and/or in print and it will not be published elsewhere in the same form, for commercial purposes, in any language, without the consent of the Publisher.