Nrf2 Signaling in Macrophages

Authors

  • Hong Zhu Campbell University Jerry M. Wallace School of Osteopathic Medicine, Buies Creek, NC 27506, USA
  • Zhenquan Jia Department of Biology, University of North Carolina, Greensboro, NC 27412, USA
  • Y. Robert Li Campbell University Jerry M. Wallace School of Osteopathic Medicine, Buies Creek, NC 27506, USA; Department of Biology, University of North Carolina, Greensboro, NC 27412, USA; Virginia Tech–Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA

Keywords:

Inflammation, Macrophages, Nrf2, Redox signaling

Abstract

The nuclear factor E2-related factor 2 (Nrf2) is known as the chief regulator of cellular antioxidant defenses as well as a suppressor of inflammation. Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to result from its upregulation of cellular antioxidant defenses via the antioxidant response element-driven transcription. In a recent article published in Nature Communications (May 23, 2016; doi: 10.1038/ncomms11624), Kobayashi et al. reported that Nrf2 suppresses transcriptional upregulation of pro-inflammatory cytokines independent of its role in regulating cellular antioxidants and redox status. This study by Kobayashi et al. provides novel insights into the molecular basis of Nrf2 acting as a suppressor of inflammation.

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Published

2016-11-01

How to Cite

Zhu, H., Jia, Z., & Li, Y. R. (2016). Nrf2 Signaling in Macrophages. Reactive Oxygen Species, 2(6), 417–420. Retrieved from https://rosj.org/index.php/ros/article/view/66

Issue

Vol. 2 No. 6 (2016)

Section

RESEARCH HIGHLIGHTS

License

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