Neonatal Intermittent Hypoxia, Reactive Oxygen Species, and Oxygen-Induced Retinopathy

Authors

  • Kay D Beharry Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA; Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA; State University of New York Eye Institute, New York, NY 10075, USA
  • Charles L Cai Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
  • Gloria B Valencia Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
  • Arwin M Valencia Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Summerlin Hospital Medical Center, Valley Healthcare System, Las Vegas, NV 89135, USA
  • Douglas R Lazzaro Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA; State University of New York Eye Institute, New York, NY 10075, USA
  • Fayez Bany-Mohammed Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of California, Irvine, CA 92868, USA
  • Jacob V Aranda Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA; Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA; State University of New York Eye Institute, New York, NY 10075, USA

Keywords:

Intermittent hypoxia oxygen-induced retinopathy, Oxidative stress, Reactive oxygen species

Abstract

Most of the major morbidities in the preterm newborn are caused by or are associated with oxygen–induced injuries and are aptly called “oxygen radical diseases in neonatology or ORDIN”. These include bronchopulmonary dysplasia, retinopathy of prematurity, periventricular leukomalacia, intraventricular hemorrhage, necrotizing enterocolitis and others. Relative hyperoxia immediately after birth, immature antioxidant systems, biomolecular events favoring oxidative stress such as iron availability and the role of hydrogen peroxide as a key molecular mediator of these events are reviewed. Potential therapeutic strategies such as caffeine, antioxidants, non-steroidal anti-inflammatory drugs, and others targeted to these critical sites may help prevent oxidative radical diseases in the newborn resulting in improved neonatal outcomes.

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Published

2017-01-01

How to Cite

Beharry, K. D., Cai, C. L., Valencia, G. B., Valencia, A. M., Lazzaro, D. R., Bany-Mohammed, F., & Aranda, J. V. (2017). Neonatal Intermittent Hypoxia, Reactive Oxygen Species, and Oxygen-Induced Retinopathy. Reactive Oxygen Species, 3(7), 12–25. Retrieved from https://rosj.org/index.php/ros/article/view/69

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Section

REVIEW ARTICLES