Total Antioxidant Capacity, Uric Acid, and Bilirubin in Patients with Heart Failure due to Non-Ischemic Cardiomyopathy

Authors

  • Celina Wojciechowska Medical University of Silesia, School of Medicine with the Division of Dentistry, Department of Cardiology, Zabrze, Poland
  • Ewa Romuk Medical University of Silesia, School of Medicine with the Division of Dentistry, Department of Biochemistry, Zabrze, Poland
  • Ewa Nowalany-Kozielska Medical University of Silesia, School of Medicine with the Division of Dentistry, Department of Cardiology, Zabrze, Poland
  • Wojciech Jacheć Medical University of Silesia, School of Medicine with the Division of Dentistry, Department of Cardiology, Zabrze, Poland

Keywords:

Bilirubin, Heart failure, Total antioxidant capacity, Uric acid, Redox state, Malondialdehyde

Abstract

The impairment of cardiac contractility in chronic heart failure might be caused by an increased level of reactive oxygen species (ROS) and/or a decrease in the antioxidant defense. Therefore, we studied total antioxidant capacity (TAC), uric acid, bilirubin, and malondialdehyde (MDA) concentrations in relation to the hemodynamic status in patients with stable heart failure. As many as 216 right heart catheterization procedures were performed in 107 patients with non-ischemic cardiomyopathy. TAC, uric acid, bilirubin, and MDA concentrations were analyzed. A comparison of groups established on the basis of the median of cardiac index (CI of 2.1 l/min/m2) and mixed venous oxygen saturation (SvO2 of 62%) was done. The results showed that significantly higher uric acid and bilirubin levels were determined in the group with CI < 2.1 l/min/m2  and in the group with SvO2 < 62%. TAC was higher in patients with lower CI. MDA concentration was similar in all subgroups. TAC correlated with stroke volume (p < 0.05), and pulmonary and systemic vascular resistance (SVRI) (p < 0.05). Both uric acid and bilirubin correlated significantly and positively with all hemodynamic parameters of pulmonary circulation and SVRI. Additionally, positive correlations between uric acid and TAC (p < 0.001) and bilirubin and uric acid (p < 0.001) were detected. On the other hand, a negative correlation between TAC and MDA (p < 0.01) was observed. In conclusion, this study revealed a novel relationship between redox state and severity of heart failure. An increase of antioxidant parameters in patients with low CI and low SvO2 may suggest an increased oxidative stress intensity and elevated compensatory mechanism in stable heart failure due to non-ischemic dilated cardiomyopathy.

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Published

2017-01-01

How to Cite

Wojciechowska, C., Romuk, E., Nowalany-Kozielska, E., & Jacheć, W. (2017). Total Antioxidant Capacity, Uric Acid, and Bilirubin in Patients with Heart Failure due to Non-Ischemic Cardiomyopathy. Reactive Oxygen Species, 3(7), 66–80. Retrieved from https://rosj.org/index.php/ros/article/view/71

Issue

Section

ORIGINAL RESEARCH