Oxidative Stress and Endoplasmic Reticulum Stress as Potential Therapeutic Targets in Non-Alcoholic Fatty Liver Disease

Authors

  • Pablo Lizana Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, CP 8380453, Santiago, Chile
  • Melissa Galdames Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, CP 8380453, Santiago, Chile
  • Ramón Rodrigo Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, CP 8380453, Santiago, Chile

Keywords:

Endoplasmic reticulum stress, Hepatocellular carcinoma, Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Oxidative stress, Reactive oxygen species

Abstract

Non-alcoholic fatty liver disease (NAFLD) is nowadays recognized as a common cause of chronic liver disease and aminotransferase elevation. Its incidence has been increasing through the last few years, raising a global prevalence of approximately 25%. The etiopathogenic mechanisms of this disease are not fully understood, but it has been related with various pathologies that compound the metabolic syndrome. Oxidative stress and endoplasmic reticulum (ER) stress have been recognized as key mechanisms in NAFLD pathogenesis. In this review, an updated overview of the role of oxidative stress and ER stress in the progression of NAFLD is provided. Besides, some current treatments focused on the above mechanisms are presented, with the objective to discuss new therapeutic strategies that could help physicians on their daily clinical practice.

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Published

2017-07-01

How to Cite

Lizana, P., Galdames, M., & Rodrigo, R. (2017). Oxidative Stress and Endoplasmic Reticulum Stress as Potential Therapeutic Targets in Non-Alcoholic Fatty Liver Disease. Reactive Oxygen Species, 4(10), 266–274. Retrieved from https://rosj.org/index.php/ros/article/view/96

Issue

Vol. 4 No. 10 (2017)

Section

REVIEW ARTICLES

License

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