Mind-Body Interventions Significantly Decrease Oxidative DNA Damage in Sperm Genome: Clinical Implications

Authors

  • Vidhu Dhawan Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
  • Manoj Kumar Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
  • Priyanka Chaurasia Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
  • Rima Dada Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India

Keywords:

Embryogenesis; Gene expression; Infertility; Meditation; Mind-body interactions; Oxidative DNA damage; Oxidative stress; Yoga

Abstract

Mind-body interventions (MBIs) have been broadly categorized into a group of interventions which facilitate mind’s capacity to affect the functions of the body. There is a growing body of evidence suggesting the adoption of MBIs like yoga, meditation, Tai Chi, and Qigong as an adjunct in the management of various complex lifestyle-related disorders. This review summarizes the importance of simple yoga- and meditation-based lifestyle intervention as a critical component of male infertility therapy. Defective chromatin integrity is one of the hallmarks of male factor infertility. Regular practice of yoga and meditation affects and targets the whole body, decreases free radical levels, and causes collateral increase in levels of antioxidants, not only resulting in improvement in standard sperm parameters, but also becoming ideal in treating oxidative stress and oxidative DNA damage and modulating levels of sperm transcripts through affecting the sperm methylome. This may aid in reversing testicular aging and improving the overall health and quality of life of male infertility patients and of the next generation.

Downloads

Published

2019-01-01

How to Cite

Dhawan, V., Kumar, M., Chaurasia, P., & Dada, R. (2019). Mind-Body Interventions Significantly Decrease Oxidative DNA Damage in Sperm Genome: Clinical Implications. Reactive Oxygen Species, 7(19), 1–9. Retrieved from https://rosj.org/index.php/ros/article/view/165

Issue

Vol. 7 No. 19 (2019)

Section

REVIEW ARTICLES

License

Submission of an original manuscript to the Journal will be taken to mean that it represents original work not previously published; that it is not being considered elsewhere for publication; that the author(s) agrees to assign copyright to the Journal upon acceptance for publication in the Journal, and if accepted for publication, it will be published in the digital format (PDF) and/or in print and it will not be published elsewhere in the same form, for commercial purposes, in any language, without the consent of the Publisher.